Product Specifications:
Contents: PT-141
Size: 10mg
Form: Lyophilized powder
Purity: >99%
Product Overview
PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and an active metabolite of Melanotan II. Derived from alpha-melanocyte-stimulating hormone, it is utilized in scientific literature to explore central nervous system

modulation of sexual motivation, melanocortin receptor dynamics, and neuroendocrine signaling.

Active Sequence: Cyclo(N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysine)
Quantity: 10 mg
Physical Form: Lyophilized powder
Purity Standard: Greater than 99% (HPLC / Mass Spectrometry verified)
Research Domain: Central neurobiology, melanocortin receptor activation, and hypothalamic pathway signaling

Mechanistic Profile in Research

Central Receptor Agonism: PT-141 binds as a non-selective agonist at central melanocortin receptors, displaying high affinity for MC3R and

MC4R within the medial preoptic area (mPOA) and hypothalamus.
Vascular-Independent Response: Unlike peripheral vasoactive compounds (e.g., PDE5 inhibitors), PT-141 acts upstream within the central nervous system to trigger downstream autonomic pathways governing sexual arousal and motivation.
Dopaminergic Interaction: Studies show that central MC4R activation by PT-141 stimulates dopamine release in the nucleus accumbens and prefrontal cortex, highlighting its role in reward and appetitive behavioral pathways.

Handling and Storage Protocol

Reconstitution: Dilute using sterile Bacteriostatic Water (0.9% Benzyl Alcohol). Direct the liquid down the inner wall of the glass vial and gently swirl to dissolve. Avoid rapid agitation.

Lyophilized Form: Store at -20 degrees C for long-term preservation; shield from light.
Reconstituted State: Store refrigerated at 2 degrees C to 8 degrees C and utilize within 28 days to prevent degradation. Avoid repeated freeze-thaw cycles.