Product Specifications:
Contents: MOTS-c
Size: 20mg and 40mg
Form: Lyophilized powder
Purity: >99%
Product Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a 16-amino-acid mitochondrial-derived peptide (MDP). Encoded directly within the mitochondrial genome rather than nuclear DNA, MOTS-c is utilized in

scientific literature to investigate cellular stress responses, systemic metabolic regulation, and exercise-mimetic pathways.

Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Available Sizes: 20mg and 40mg
Physical Form: Lyophilized powder
Purity Standard: Greater than 99% (HPLC / Mass Spectrometry verified)
Research Domain: Mitochondrial biology, metabolic homeostasis, and cell-autonomous signaling

Mechanistic Profile in Research

AMPK Activation & Folate Cycle Intermediates: MOTS-c regulates metabolic homeostasis by targeting the folate cycle and inhibiting de novo purine synthesis. This leads to the accumulation

of AICAR (an endogenous intermediate) and subsequent activation of AMP-activated protein kinase (AMPK).
Insulin Sensitivity & Glucose Uptake: In cellular and animal models, MOTS-c promotes GLUT4 translocation in skeletal muscle, enhancing glucose clearance independently of classical insulin receptor pathways.
Retrograde Nuclear Translocation: Under metabolic stress, MOTS-c translocates from the mitochondria to the nucleus. There, it binds to specific regulatory regions alongside transcription factors like NRF2 to regulate antioxidant gene expression and cellular stress responses.
Metabolic Flexibility & Fat Oxidation: Research indicates that MOTS-c administration supports fatty acid oxidation and blunts diet-induced metabolic dysfunction in animal models.

Handling and Storage Protocol

Reconstitution: Dilute using sterile Bacteriostatic Water (0.9% Benzyl Alcohol) or standard sterile saline (0.9% NaCl). Direct the diluent slowly down the glass vial wall and gently swirl until fully dissolved. Do not shake vigorously.
Lyophilized Form: Store at -20 degrees C for long-term preservation; protect from light exposure.
Reconstituted State: Keep refrigerated at 2 degrees C to 8 degrees C and use within 28 days to maintain compound stability. Avoid repeated freeze-thaw cycles.

This product is provided strictly for laboratory research and analytical testing by qualified scientific professionals. It is not approved for human or veterinary administration, diagnostic protocols, or therapeutic applications.