Product Specifications:Contents: CJC-1295 without DAC
Size: 5mg, 10mg
Form: Lyophilized powder
Purity: >99%

Product Overview
CJC-1295 (no DAC), also known as Modified

GRF (1-29), is a 29-amino-acid synthetic peptide analogue of growth hormone-releasing hormone (GHRH). It is utilized in scientific literature to investigate short-acting, pulsatile growth hormone (GH) secretion and pituitary axis feedback mechanisms.

Active Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Quantity: 5 mg
Physical Form: Lyophilized powder
Purity Standard: Greater than 99% (HPLC / Mass Spectrometry verified)
Research Domain: Endocrine signaling, anterior pituitary secretion, and metabolic regulation

Mechanistic Profile in Research

Pulsatile GH Release: Modified GRF (1-29) binds

to the GHRH receptor on pituitary somatotropes, triggering a natural, transient spike in growth hormone secretion that mimics endogenous physiological release.
Absence of Drug Affinity Complex (DAC): Without the affinity-complex linker that binds serum albumin, CJC-1295 (no DAC) has a short half-life (approximately 30 minutes in research models), preventing continuous, non-physiological elevation of GH levels.
Synergy with GHRPs: In research models, co-administration with growth hormone secretagogues (like Ipamorelin or GHRP-2) produces a synergistic effect on GH release by acting through distinct but complementary receptor pathways.
IGF-1 Downstream Signaling: Studies measure downstream hepatic expression of Insulin-like Growth Factor 1 (IGF-1) following pulsatile GHRH stimulation to evaluate systemic anabolic

signaling.

Handling and Storage Protocol

Reconstitution: Dilute using sterile Bacteriostatic Water (0.9% Benzyl Alcohol). Direct the diluent slowly down the inside glass wall of the vial and gently swirl until fully dissolved. Do not shake vigorously.
Lyophilized Form: Store at -20 degrees C for long-term preservation; protect from ambient light.
Reconstituted State: Keep refrigerated at 2 degrees C to 8 degrees C and use within 28 days to preserve molecular stability. Avoid repeated freeze-thaw cycles.

This product is provided strictly for laboratory research and analytical testing by qualified scientific professionals. It is not approved for human or veterinary administration, diagnostic

protocols, or therapeutic applications.